32 unique references to scientific papers. Avoid use if hypersensitive to any of the components of product. No alterations in Apolipoprotein B have been noted, No significant influence of Pueraria lobata on circulating estrogen levels (although it itself may be a phytoestrogen; weak). If undergoing medical therapies, then consult with your respective Therapist or Health Care Professional about possible interactions between your Treatment, any Pharmaceuticals or Drugs being given, and possible nutritional supplements or practices hosted on Examine.com. Most commercial products containing pueraria are available as rejuvenating, antiaging, or skin-lightening creams or gels, as beauty soaps, or as capsules or tablets for increasing appetite, enlarging breasts, modulating hair growth or regrowth, and other rejuvenating purposes. The plant genus Pueraria is named after the Swiss Professor M. N. Pueraria (1766-1845). Puerarin acts through brain serotonergic mechanisms to induce thermal effects. The length of the menstrual cycle increased in monkeys treated with P. mirifica 10 and 100 mg/day of root extract and disappeared completely in monkeys treated with root extract 1,000 mg/day. May Support Vaginal Health. The pueraria lobata plant has been used in medical treatments for hundreds of years, and the root, flower, and leaf can all be utilized. Examine.com is intended to be used for educational and information purposes only. Pueraria Lobata Root Extract is an extract of the roots of Pueraria lobata, Fabacea 11. It is applied in pharmaceutical field, pueraria isoflavones is widely used in biopharmaceuticals and API of cardiovascular system agents in China. 319 pueraria lobata root products are offered for sale by suppliers on Alibaba.com, of which herbal extract accounts for 23%, other extracts accounts for 7%. mirifica also had an estrogenic effect on a human HepG2 hepatoma cell line that contained an estrogen receptor and a luciferase reporter gene; this evidence indicates that metabolic activation of P. mirifica promotes estrogenic activity.Lee 2002 Another study also documents that estrogenic activity may result from metabolic activation of liver enzymes.Cherdshewasart 2008, The proposed mechanism of action involves strong competitive binding of the plant's phytoestrogens to ER-alpha and/or synthesis suppressor of ER-alpha.Cherdshewasart 2007, Pretreatment of rats with P. mirifica (1,000 mg/kg body weight per day tuberous root powder) resulted in decreased virulence of rat mammary tumor development from 7,12-dimethylbenz(a)anthracene (7,12-DMBA). Available for Android and iOS devices. The direction and size of the supplement's impact on Psychopharmacology (Berl). Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect. A comparative study on aqueous root extracts of Pueraria thomsonii and Pueraria lobata by antioxidant assay and HPLC fingerprint analysis. The benefits of Pueraria are seemingly endless; some people use it to alcoholism, heart and circulatory problems, upper respiratory problems, and skin problems. A comparative study on aqueous root extracts of Pueraria thomsonii and Pueraria lobata by antioxidant assay and HPLC fingerprint analysis. The report provides an understanding of the global Pueraria Lobata Root Extract industry competitors, â¦ Scientific research does not always agree. to see the full set of research information and references for Pueraria lobata. followed by specifically-applicable references. P. mirifica may greatly alter the length of menstrual cycles and suppress ovulation by reducing serum levels of gonadotropins. Efficacy and Safety of Pueraria lobata Extract in Gray Hair Prevention: A Randomized, Double-Blind, Placebo-Controlled Study. No significant influence on circulating LDL-C has been noted with supplementation. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Each member of our research team is required to have no conflicts of interest, including with supplement manufacturers, food companies, and industry funders. No significant influence detected on symptoms of menopause (as assessed by rating scales), No significant influence have been detected on total cholesterol. The team includes nutrition researchers, registered dietitians, physicians, and pharmacists. turmeric, echinacea, saw palmetto, milk thistle, Ginkgo Biloba. We are 100% backed by science. Select one or more newsletters to continue. This page features 32 references. Kudzu (Pueraria lobata) is one of the earliest medicinal plants used in traditional Chinese medicine. In rabbits, P. mirifica improved endothelial function through a nitric oxide pathway, decreased contractile responses to norepinephrine, and increased responses to estradiol. Nevertheless, toxicological data on these herbs and their combination are limited. Fu-Liang X, Xiao-Hui S, Lu G, Xiang-Liang Y, Hui-Bi X. Puerarin protects rat pancreatic islets from damage by hydrogen peroxide. "Pueraria lobata," Examine.com, published on 30 September 2013, last updated on Kudzu Liquid Extract, Organic Kudzu (Pueraria lobata) Dried Root Tincture Features and description: NON GMO! there is, and how strong these effects are. She is known worldwide as The Cosmetics Cop and creator of Paulaâs Choice Skincare. https://examine.com/supplements/pueraria-lobata/, © 2011-2020 Examine.com Inc | Privacy | Terms of Service | Disclaimer | About Us | Contact Examine.com, Small boost in attention in menopausal women (independent of reductions in symptoms of menopause); needs to be reinvestigated. Pure, high quality Kudzu root extract. High Quality Kudzu liquid extract - we use classic conventional methods of â¦ All factual claims are followed by specifically-applicable references. The mechanism underlying anti-obesity effect of RP was investigated in high-fat diet (HFD) induced obese mice and skeletal muscle cells (C2C12). Medically reviewed by Drugs.com. Examine.com and its Editors do not advocate nutritional supplementation over proper medical advice or treatment and this sentiment will never be expressed through pages hosted under Examine.com. for this page. Most commercial products containing pueraria are available as rejuvenating, antiaging, or skin-lightening creams or gels, as beauty soaps, or as capsules or tablets for increasing appetite, enlarging breasts, modulating hair growth or regrowth, and other rejuvenating purposes. Some of the isoflavonoids in P. mirifica had antioxidant activity similar to that of alpha tocopherol or vitamin E.Cherdshewasart 2008P. Other Common Names: Kudzu vine, Japanese arrowroot, ge gen (ge hua) (Chinese), bidari kand (Sanskrit). Enter your email and we'll keep you on top of the latest nutrition research, supplement myths, and more. Some clinical studies used 200 to 400 mg (extracted from the root or tuber) by mouth per day. Click here to see the full set of references This product may adversely interact with certain health and medical conditions, other prescription and over-the-counter drugs, foods, or other dietary supplements. Commercial manufacturers suggest a dosage of 250 mg of active ingredients from the root orally every morning and evening. Pueraria (gegen), the root of Pueraria lobata, is a commonly used herb in Chinese medicine. It contains around 20 species of herbaceous or woody vines, all native to Asia. ITM: Pueraria: Source of Important Isoflavones, by Subhuti Dharmananda, Ph.D., Director, Institute for Traditional Medicine, Portland, Oregon. This is only a brief summary of general information about this product. Serum FSH, LH, estradiol, progesterone, and immunoreactive-irinhibin were lower in a dose-dependent manner during treatment. Because of pueraria's estrogen-like effect, use with caution in patients with asthma, diabetes mellitus, epilepsy, migraine, or systemic lupus erythematosus. What makes it difference is the amount of its active compound called Phytoestrogen. A small (n= 52) clinical study evaluated oral P. mirifica at 25 and 50 mg over 6 months in relieving menopausal symptoms, and reported efficacy for both doses. The Human Effect Matrix summarizes human studies to tell you what effects Use with caution in patients with abnormal triglycerides or hypercalcemia. We comply with the HONcode standard for trustworthy health information -. 150+ studies summarized across 25 different categories every month. Become an Examine.com member to get access to the latest research. The plant caused no changes in lipid profile or liver enzymes.Wattanapitayakul 2005 In male and female gonadectomized rats, P. mirifica had estrogen-like activity and affected accessory sex organs. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this product. Pueraria Lobata Root Extract Applications: 1. Rating: Best; Categories: Antioxidants, Plant Extracts; See kudzu root Back to Ingredient Dictionary. The main ingredient of Pueraria extract. 14 June 2018, Pueraria mirifica is sometimes used as an anti-aging supplement or as a natural remedy for menopausal symptoms such as hot flashes and vaginal dryness. Buy Kudzu (Pueraria Lobata) Tincture, Organic Dried Roots Liquid Extract 2 oz on Amazon.com FREE SHIPPING on qualified orders At higher doses, it increased bone density without affecting accessory sex organs.Urasopon 2007 In a similar study, P. mirifica completely inhibited bone loss in long bones and axial bones in estrogen-deficient female rats.Urasopon 2008 However, the highest dose of P. mirifica root powder (1,000 mg/kg body weight per day) caused an undesired adverse reaction of increased uterine weight. Other name:kudzu root extract,Kudzuvine Root extract,pueraria lobata extract Plant Origin: Pueraria lobataï¼Willd.ï¼Ohwi . For topical products, manufacturers suggest a twice-daily topical application to the breast area for 3 to 5 minutes until fully absorbed. Thin-layer chromatography analysis has documented varying amounts of phytoestrogens collected from P. mirifica in different locations in Thailand.Malaivijitnond 2006, Cherdshewasart 2007 One of the challenges of large-scale manufacturing of P. mirifica for drugs and cosmetics is resolving these variations in lots. Directions: Adults take 1 capsule daily with food or as directed by your doctor and/or qualified health professional. 11 Cosmetics Ingredients containing PUERARIA LOBATA ROOT EXTRACT. Anti-aging Agents (3) Anti-inflammatories (3) Anti-wrinkle Agents (1) Antimicrobials (1) Antioxidants (5) Habitat: Kudzu is native to India, China, and Japan. This information does not endorse this product as safe, effective, or approved for treating any patient or health condition. iCrowdNewswire Oct 15, 2020 9:15 AM ET. Pueraria lobata. Safety evaluation of root extract of Pueraria lobata and Scutellaria baicalensis in rats. Get our free 5-day course on the essentials of supplementation. Histopathological analysis of the mammary tumor tissues revealed lower ER-alpha, ER-beta, and ER-alpha/ER-beta profile.Cherdshewasart 2007, Cognitive improvements were reported in ovariectomized rats administered P. mirifica extract and pure puerarin, with the researchers suggesting potential applications in cognitive decline due to ageing.Anukulthanakorn 2016, The active ingredients from the root of P. mirifica had lethal properties during various growth cycles against the yellow fever mosquito (Aedes aegypti) and other mosquito species with disease-spreading abilities.Lapcharoen 2005. That's why we don’t sell any advertising or supplements. The blue-to-purple flowers are composed of 5 petals and bloom from February to March. You should talk with your health care provider for complete information about the risks and benefits of using this product. The lone study on Kudzu root used a product containing 100mg of isoflavone equivalents, which appeared to be slightly effective for promoting cognition in postmenopausal women. Make informed decisions about your health, https://examine.com/supplements/pueraria-lobata/, Robust research conducted with repeated double-blind clinical trials, Multiple studies where at least two are double-blind and placebo controlled, Single double-blind study or multiple cohort studies, Uncontrolled or observational studies only. This information is not specific medical advice and does not replace information you receive from your health care provider. Highest Strength Kudzu liquid extract! This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. The tuberous roots of P. mirifica primarily contain the active component miroestrol and its derivative, deoxymiroestrol.Chansakaow 2000 The tuberous roots of P. mirifica also contain daidzin, daidzein, genistin, genistein, puerarinIngham 1986 mirificoumestan, kwakhurinIngham 1986, Tahara 1987 coumestrolIngham 1988 mirificin, and 2 steroids, estrone and estriol.Sookvanichsilp 2008, Ingham 1986, Ingham 1989, Chansakaow 2000 The manufacture and synthesis of miroestrol is documented.Corey 1993, Ishikawa 2006 Deoxymiroestrol was isolated and identified as the most active phytoestrogen of the plant.Cherdshewasart 2004, Sookvanichsilp 2008, Ishikawa 2001. Also use with caution in patients with abnormal triglyceridesManonai 2008 or hypercalcemia.Manonai 2008, Urasopon 2007, Urasopon 2008, High doses of P. mirifica caused general and genotoxicity in animals.Saenphet 2005 Rats treated with aqueous and ethanolic root extracts of P. mirifica had significantly lower body weight gain and lower packed red cell volume; the plant also had mutagenic activity.Sanchanta 2005 A root extract dosage of 100 mg/kg had adverse effects on mating efficiency and reproduction in female mice.Jaroenporn 2007 No estrogen hormone activities were found in egg and chicken meat tissue or rats.Tubcharoen 2003, Tubcharoen 2003 The median lethal dose for oral consumption of P. mirifica root powder in mice was 2,000 mg/kg body weight per day.Cherdshewasart 2003. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. A standardized kudzu extract (NPI-031) reduces alcohol consumption in nontreatment-seeking male heavy drinkers. 2012;20(1):17-23. Arm yourself with the knowledge you need to make the right decisions about your health. Each member of our research team is required to have no conflicts of interest, including with supplement It is unsure if this is near the optimal dosage or not. Kudzu (Pueraria lobata) Root Extract 40% Flavonoids. The plant's palmate-type leaves are simple or ovate and contain 3 leaflets in 1 petiole. 12. 1-4-2005;96(1-2):133-138. There was no change in blood cells or liver and renal function.Hosoyama 2007, Muangman 2001. Our evidence-based analysis on pueraria lobata features 32 unique references to scientific papers. Radix Pueraria lobata (RP) has been reported to prevent obesity and improve glucose metabolism; however, the mechanism responsible for these effects has not been elucidated. With the exception of certain products that are generally recognized as safe in normal quantities, including use of folic acid and prenatal vitamins during pregnancy, this product has not been sufficiently studied to determine whether it is safe to use during pregnancy or nursing or by persons younger than 2 years of age. We have a strict editorial process. Pueraria mirifica may be an effective topical therapy for promoting â¦ Commercial products are available in topical (creams, gels, and soaps) or oral (capsules or tablets) dosage forms. The tuberous root varies in size depending on soil condition, but may weigh as much as 100 kg. It is important to fully inform your doctor about the herbal, vitamins, mineral or any other supplements you are taking before any kind of surgery or medical procedure. Category. Jo SJ, Shin H, Paik SH, et al. The latest published report namely Global Pueraria Lobata Root Extract Market Growth 2020-2025 added by MarketandResearch.biz offers an insightful take on the historical data of the market and predictions for 2020 to 2025 time-period. J Pharmacol Sci 2004;96:420-7. Examine.com does not assume liability for any actions undertaken after visiting these pages, and does not assume liability if one misuses supplements. the roots and flowers of kudzu, Radix and Flos puerariae, respectively, have been used to treat alcohol abuse safely and effectively in China for more than a millennium. Ann Dermatol. This information relates to an herbal, vitamin, mineral or other dietary supplement. December 2020; BMC Complementary Medicine and Therapies 20(1) DOI: 10.1186/s12906-020-02998-1. This product has not been reviewed by the FDA to determine whether it is safe or effective and is not subject to the quality standards and safety information collection standards that are applicable to most prescription drugs. Another component, known as PE-D, affected the growth in a dose-dependent and time-dependent manner on some breast cancer cell lines (MCF-7, MDAMB-231), and on the growth of ovarian (2774) and cervical cancer cells (HeLa).Baek 2003, Jeon 2005 The estrogenic effect of some components in P. mirifica has been compared with estradiol, a major estrogen in humans.Jeon 2005, Cherdshewasart 2008 The rank order of phytoestrogen potency is: deoxymiroestrol; miroestrol; 8-prenylnaringenin; coumestrol; genistein/equol; daidzein; resveratrol.Matsumura 2005P. In postmenopausal osteoporotic monkeys oral administration of P. mirifica improved both bone quality and quantity.Kittivanichkul 2016. The main plant sources of Pueraria extract are the dried roots of Pueraria Lobata Willd Ohwi or Pueraria Thomsonii Bentn, which are commonly known as âPueraria Lobataâ. It is applied in food field, pueraria isoflavones can lower blood pressure 2. This page is regularly updated, to include the most recently available clinical trial evidence. We have a strict editorial process. We initiated the project by searching the possible target of the Pueraria lobata root extract (P. lobata).We conducted the IC 50 assays of P. lobata on the four diabetes-related proteins: PTP1B, TCPTP, SHP-2 and DPP-4. Bonus: unlock the supplement Human Effect Matrix and all health topics on Examine.com. 13. For breast enlargement, manufacturers suggest a twice-daily topical application to the breast area for 3 to 5 minutes until fully absorbed. Five-week-old C5BL/6 mice were fed a HFD containing or not â¦ Commercial products are available as topical creams, gels, and soaps, or in oral capsule and tablet dosage forms.Sookvanichsilp 2008, Malaivijitnond 2006, Chansakaow 2000, Liang 2000, Roufs 2007, Yagi 2007, Tehara 2006, Liu 2005, Konoike 2006, Ishiwatari 2003 Some clinical studies used 200 to 400 mg extract from root or tuber orally per day. Background: the â¦ ï»¿ ï»¿ The root of the plant contains compounds classified as phytoestrogens, meaning that they have estrogen-like effects. dietitians, physicians, and pharmacists. View abstract. Gluten Free! Kudzu is being investigated for its potential use as a therapy for alcoholism; however, sufficient and consistent clinical trials are lacking. Study: The Chinese Pueraria root extract (Pueraria lobata) ameliorates impaired glucose and lipid metabolism in obese mice. The researchers suggest 1 mg of P. mirifica is equivalent to 0.52 to 0.75 mcg of ethinyl estradiol.Virojchaiwong 2011, Similar to findings in monkeys,Jaroenporn 2014 a randomized clinical study (n=82) reported P. mirifica gel to be effective in improving signs of vaginal atrophy and restoring vaginal epithelium at 6 and 12 weeks, but to a lesser extent than conjugated estrogen cream.Suwanvesh 2017, In small clinical trials, the administration of P. mirifica crude extract improved hot flushes, frustration, sleep disorder, skin dryness, high blood cholesterol, amenorrhea, and other menopause-related symptoms in women. The estrogenic activity of kudzu and the cardioprotective effects of its constituent puerarin are also under investigation, but clinical trials are limited. Increased triglyceride levels may occur.Manonai 2008, Because of the estrogen-like effect of P. mirifica, use with caution in patients with asthma, diabetes mellitus, epilepsy, migraine, or systemic lupus erythematosus. Kudzu liquid extract contains ONLY natural ingredients! 32 unique references to scientific papers. This product may be unsafe when used before surgery or other medical procedures. The plant species P. mirifica (pueraria) belongs to the Fabaceae, or bean, subfamily, and its tuberous roots contain several phytoestrogens.Manonai 2007 P. mirifica is a woody vine commonly found in forests throughout ThailandMalaivijitnond 2006 with 28 cultivars presently documented. Pueraria lobata â Kudzu New! May affect concentration of these medications. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. A Puerariae radix extract has been shown to mitigate liver injury and lipid accumulation induced by chronic alcohol intake, 108 that has been attributed to three major isoflavonoids present in this plant â puerarin, daidzin, and daidzein. This item: Kudzu Alcohol-Free Liquid Extract, Organic Kudzu (Pueraria lobata) Dried Root Glycerite Hawaii Pharmâ¦ $24.95 ($12.48 / 1 Fl Oz) In Stock. A small boost in cognition in menopausal women given the supplement; needs to be replicated and uncertain if it applies to otherwise healthy youth. Chiang HM, Fang SH, Wen KC, et al. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. At Examine.com, our incentives line up with yours — getting unbiased information. May decrease serum free thyroxine concentrations. Latin Name:Radix Puerariae Appearance:Brown Fine Powder to White crystalline solid Extracted part: Root Specification: Pueraria Isoflavones 40%~99% HPLC/UV Puerarin 15%-99% HPLC Its ingredients are isoflavonoids, tripenoids, coumarins, etc. It is perhaps better known by its Japanese name: kudzu. Results indicated that P. lobata exhibited high PTP1B inhibitory activity with IC 50 of â¦ This information should not be used to decide whether or not to take this product. The researchers suggest 1 mg of P. mirifica is equivalent to 0.52 to 0.75 mcg of ethinyl estradiol.Virojchaiwong 2011. Its root is also fast growing, typically reaching 50 pounds or more, and can attain a weight of 400 pounds (about 2/3 of it is water). Phytoestrogens have estrogen-like effects. Paula Begoun is the best-selling author of 20 books about skincare and makeup. Our independent, unbiased approach reveals what works (and what's a waste of time and money). Click here HIGH or Overall activity was more potent in female rats than in male rats. Join over 250,000 people who have learned about effective versus overrated supplements, tips for buying supplements, and how to combine supplements for safety and efficacy. Kudzu (Pueraria lobata) is one of the earliest medicinal plants used in traditional Chinese medicine. Because of its phytoestrogen-like effects, use pueraria with caution if diagnosed with an estrogen-dependent neoplasia, pulmonary embolism, liver dysfunction or disease, or anemia. Pueraria lobata 1:2 Fluid extract Common Names: Kudzu, Japanese Arrowroot, Gegen Botanical family: Fabaceae Part Used: Root, flower Dosage: 25-70 ml per week Primary Active Constituents: Isoflavones including puerarin, daidzin, daidzein, genistin, genistein, tectorigenin, glycitin, Sold by QUALITY HERBAL EXTRACTS (Sense LLC) and ships from Amazon Fulfillment. This page features 32 references. Pueraria Mirifica (same genera, different herb), Japanese Knotweed (also called Kudzu), Angelica dahurica (enhances absorption of Puerarin from Pueraria Lobata), Savlia Miltiorrhiza (Danshen) for anti-inflammatory purposes. The combination was blended overnight in a rotating mixer and pelleted (Test Diet, Richmond, IN). Phytomedicine. No significant alterations in luteinizing hormone has been detected with pueraria lobata ingestion. Servings per Container: 50. It increased luteinizing hormone (LH) and follicle-stimulating hormone (FSH) in both sexes.Malaivijitnond 2004 The mechanism of action involved direct stimulation of the accessory sex organs and suppression of the hypothalamic-pituitary-gonadal axis. Pueraria lobata has on your body, how much evidence A wide variety of pueraria lobata root options are available to you, There are 130 suppliers who sells pueraria lobata root â¦ Prasain JK, Peng N, Rajbhandari R, Wyss JM. Background: The roots of Pueraria lobata and Scutellaria baicalensis, herbal medicines with a long history of widespread use, have been traditionally prescribed in combination to treat stroke, diabetes, and acute infectious diarrhea in East Asia. VERY HIGH means that most of the scientific research agrees. In sex-hormone–deficient male rats, treatment with P. mirifica root powder completely inhibited bone loss in long bones and axial bones. Scientific Name(s): Pueraria mirifica Airy Shaw et. The plant species is rich in phytoestrogens, and postmenopausal women in Thailand have consumed it for more than 100 years citing its beneficial estrogen effects.Manonai 2008 In traditional Thai medicine, it is common to use P. mirifica as a skin moisturizer, to improve regrowth of hair, to improve body flexibility and sexual performance, and to firm and enlarge the breasts.Malaivijitnond 2006 Commercial products containing pueraria are continually introduced into the world marketSookvanichsilp 2008 and have become popular in Thailand, Korea, and Japan.Malaivijitnond 2006 Most commercial products are available as topical rejuvenating, antiaging, or skin-lightening creams or gels, as beauty soaps, or as capsules or tablets for increasing appetite, enlarging breasts, modulating hair growth or regrowth, and other rejuvenating purposes.Sookvanichsilp 2008, Malaivijitnond 2006, Chansakaow 2000, Liang 2000, Roufs 2007, Yagi 2007, Tehara 2006, Liu 2005, Konoike 2006, Ishiwatari 2003 Since 1999, domestic and global demand for the raw materials from P. mirifica roots or tubers has increased, resulting in intense harvesting of the plant from the forests of Thailand.Cherdshewasart 2007, Isoflavones, coumestans, and lignans are the 3 main classes of phytoestrogens. Suvatabhandu.Common Name(s): Kwao Keur, Kwao Krua, Kwao Kruea, White Kwao Krua. Toxicol Appl Pharmacol 2005;209:263-8. manufacturers, food companies, and industry funders. Supplement Facts. However, there is no literature to support these uses. Becoming a member also unlocks our study database of 400+ supplements and their effects on 600+ health outcomes. Theoretically, drug interactions may occur with the following: May increase pharmacologic and toxicologic effects. the roots and flowers of kudzu, Radix and Flos puerariae, respectively, have been used to treat alcohol abuse safely and effectively in China for more than a millennium. However, there is no literature to support these uses. each outcome. Examine.com and its Editors do not ensure that unforeseen side effects will not occur even at the proper dosages, and thereby does not assume liability for any side effects from supplements or practices hosted under the domain of Examine.com. J Ethnopharmacol. Chemical constituents of Kudzu Root extract About the Experts. Iso Manufacturer Supply Natural Pueraria Lobata Extract Powder , Find Complete Details about Iso Manufacturer Supply Natural Pueraria Lobata Extract Powder,Pueraria Lobata Powder,Pueraria Lobata Extract from Herbal Extract Supplier or Manufacturer-Xian Pincredit Bio-Tech Co., Ltd. Kudzu Root Extract. Last updated on Jul 27, 2020. Our evidence-based analysis on pueraria lobata features View abstract. The team includes nutrition researchers, registered Chueh FS, Chang CP, Chio CC, Lin MT. Commercial manufacturers suggest 250 mg (root or tuber) by mouth every morning and evening. The medical literature documents the plant's use primarily for menopause, but also for cancer and osteoporosis. All factual claims are The experimental diet was made by adding powdered Pueraria root extract (0.2% w/w) to AIN-93M, a phytoestrogen-free diet (see Reeves et al, 1993 for a full description of this diet). mirifica phytoestrogens at a dose of root extract 1,000 mg/day decreased serum parathyroid hormone and calcium levels in aged menopausal monkeys and, thus, may be beneficial in treating bone loss caused by estrogen deficiency.Trisomboon 2004P. During the posttreatment period, only monkeys treated with P. mirifica 10 and 100 mg/day of extract recovered from the changes in menstrual cycle length and hormone levels.Trisomboon 2005 Other studies document similar activity for the P. mirifica 1,000 mg/day dose of Trisomboon 2004 root extract and the direct correlation in dose with gonadotrophin levels.Trisomboon 2006, The plant had a dose-dependent estrogenic effect on rat vaginal cornification.Cherdshewasart 2007P. The ethanol extract had antiproliferative effects on breast cancer cell lines MCF-7, ZR-75-1, MDA-MB-231, SK-BR-3, and Hs578T. Avoid use during pregnancy and lactation because of the lack of clinical data and the plant's phytoestrogen activity. Type 2 diabetes mellitus is a fast-growing epidemic affecting people globally. Become an Examine Personalized member to access the latest nutrition research on over 400 supplements across more than 600 different health goals, outcomes, conditions, and more. Pueraria Lobata (Kudzu) is a root plant that appears to have traditional usage in alleviating migraines and hangovers. If using any pharmaceuticals or drugs given to you by a doctor or received with a prescription, you must consult with the doctor in question or an equally qualified Health Care Professional prior to using any nutritional supplementation. The medical literature documents the plant's use primarily for menopause, but also for cancer and osteoporosis. It is a fast growing vine that can extend a foot in length each day during the warm season. No significant alterations have been noted in follicle-stimulating hormone concentrations following pueraria lobata ingestion. The Chinese Pueraria root extract (Pueraria lobata) ameliorates impaired glucose and lipid metabolism in obese mice. Pueraria Mirifica is a tropical herb that originated in Thailand which is known to have highest compound than its family plant while Pueraria Lobata or Kudzu root has its own origin in China. mirifica decreased neuronal cell death in a time- and dose-dependent manner against neurotoxic agents in an Alzheimer disease model in vitro.Sucontphunt 2007, Sawatsri 2004 Mechanism of action may be associated with an effect on synaptic density by inducing synaptophysin expression via estrogen receptor.Chindewa 2008, Spinasterol, an active cytotoxic component of P. mirifica, was active against certain gynecological cancer cell lines and activates estrogen receptors ER-alpha and ER-beta. 2013 Mar;226(1):65-73. Search by keywords . 15588661 mirifica had an estrogenic action in aged menopausal monkeys by changing the sexual skin area around the perineum to the base of the tail to a reddish pigmentation.Trisomboon 2006 FSH may be a candidate marker for the study of P. mirifica's estrogenic effects in female monkeys if changes in urinary hormones are used as an indicator.Trisomboon2007, Trisomboon 2007, In a 24-week randomized, double-blind, placebo-controlled trial of 51 postmenopausal women, oral P. mirifica exhibited estrogenicity on vaginal tissue, alleviated vaginal dryness symptoms and dyspareunia, improved signs of vaginal atrophy, and restored atrophic vaginal epithelium.Manonai 2007 In another clinical trial of 51 postmenopausal women 46 to 60 years of age, P. mirifica tuberous root had an estrogen-like effect on bone turnover rate at a dose of 20, 30, and 50 mg/day for a 24-week period.Manonai 2008 Phase 1 to 3 trials in Thailand compared the estrogenic effect of P. mirifica to conjugated equine estrogen in relieving climacteric symptoms in perimenopausal women.Lamlertkittikul 2004, Chandeying 2007, A small (n=52) clinical study evaluated oral P. mirifica at 25 and 50 mg over 6 months in relieving menopausal symptoms, and reported efficacy for both doses. Menopausal symptoms; general female reproductive health; support of bone, hair, and fingernails; sexual longevity including vaginal lubrication; and enhanced breast size. View abstract. Information tailored to you, updated every month. J Ethnopharma col 1-4-2005;96(1-2):133-138. Pueraria mirifica is a plant native to Thailand and Burma. Botanical Name: Pueraria lobata. extract of pueraria lobata, pueraria lobata (kudzu) root extrac, pueraria lobata (kudzu) root extract, pueraria lobata extract, and pueraria lobata root extract Cancer Cancer: Ingredients linked to cancer in government, industry or academic studies or assessments. Studies in mice found that P. mirifica does not affect male fertility or the hypothalamus-pituitary-testis axis.Jaroenporn 2006 The testis, epididymis, and seminal vesicle all had normal histopathology in P. mirifica -treated male mice. Data sources include IBM Watson Micromedex (updated 2 Nov 2020), Cerner Multum™ (updated 2 Nov 2020), ASHP (updated 23 Oct 2020) and others. Life-threatening interaction between the root extract of Pueraria lobata and methotrexate in rats.